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Alcohol acts as a blood thinner. I imagine it would have a small effect on swelling. However, I am more likely to believe that your buddy drinking on the night of his injury was just experiencing additional swelling from the injury itself. Also, if he had enough to make him think the booze was the cause I lean towards a tweak of the knee while heading to the bathroom, or not following RICE in the first 48 hours. I wouldn't worry about it.
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