[hitmanrva1]

Originally Posted by Sledge Hammer

1: Mol Cell Biochem. 2003 Feb;244(1-2):95-104. Links

Long-term creatine supplementation does not significantly affect clinical markers of health in athletes.
Kreider RB, Melton C, Rasmussen CJ, Greenwood M, Lancaster S, Cantler EC, Milnor P, Almada AL.
Exercise and Sport Nutrition Laboratory, Department of Human Movement Sciences and Education, The University of Memphis, Memphis, TN, USA. Richard_Kreider@baylor.edu
Creatine has been reported to be an effective ergogenic aid for athletes. However, concerns have been raised regarding the long-term safety of creatine supplementation. This study examined the effects of long-term creatine supplementation on a 69-item panel of serum, whole blood, and urinary markers of clinical health status in athletes. Over a 21-month period, 98 Division IA college football players were administered in an open label manner creatine or non-creatine containing supplements following training sessions. Subjects who ingested creatine were administered 15.75 g/day of creatine monohydrate for 5 days and an average of 5 g/day thereafter in 5-10 g/day doses. Fasting blood and 24-h urine samples were collected at 0, 1, 1.5, 4, 6, 10, 12, 17, and 21 months of training. A comprehensive quantitative clinical chemistry panel was determined on serum and whole blood samples (****bolic markers, muscle and liver enzymes, electrolytes, lipid profiles, hematological markers, and lymphocytes). In addition, urine samples were quantitatively and qualitative analyzed to assess clinical status and renal function. At the end of the study, subjects were categorized into groups that did not take creatine (n = 44) and subjects who took creatine for 0-6 months (mean 4.4 +/- 1.8 months, n = 12), 7-12 months (mean 9.3 +/- 2.0 months, n = 25), and 12-21 months (mean 19.3 +/- 2.4 months, n = 17). Baseline and the subjects' final blood and urine samples were analyzed by MANOVA and 2 x 2 repeated measures ANOVA univariate tests. MANOVA revealed no significant differences (p = 0.51) among groups in the 54-item panel of quantitative blood and urine markers assessed. Univariate analysis revealed no clinically significant interactions among groups in markers of clinical status. In addition, no apparent differences were observed among groups in the 15-item panel of qualitative urine markers. Results indicate that long-term creatine supplementation (up to 21-months) does not appear to adversely effect markers of health status in athletes undergoing intense training in comparison to athletes who do not take creatine.
PMID: 12701816 [PubMed - indexed for MEDLINE]

good shit, do you have any other studies?
what about a study on if even longer use of creatine can affect the body?

[Donut62]

I don't think I've had a weight workout in 3 years that I didn't consume creatine in a drink after. People act like it's a fucking drug or something. "I'm going to cycle of protein for a few weeks".

[Hbs6]

creatine is safe, provided adequate hyrdration and healthy kidneys to begin with...Cycling creatine was in back when "loading" was the way to take to take it..people need to read more.

[hardheart]

Good stuff and is definitive reinforcement that creatine is safe, which is what I think they were aiming at. IIRC, this was done at the request of the NCAA which was threatening to ban creatine unless it was proven to be safe. And well, there have been "impartial" studies done that showed cigarette smoking to be "safe" done also.

What you should have bolded was:

In addition, no apparent differences were observed among groups in the 15-item panel of qualitative urine markers.

The only thing that really jumps out to me is that I'm having a hard time finding a full publication of this study, and I have access to EVERYTHING published in the US. I'd like to look in to what the urine and blood markers were, and whether or not they were measuring creatinin levels.

[Sonny]

I usually cycle creatine as a result of laziness.

[Sledge Hammer]

Originally Posted by hardheart

Good stuff and is definitive reinforcement that creatine is safe, which is what I think they were aiming at. IIRC, this was done at the request of the NCAA which was threatening to ban creatine unless it was proven to be safe. And well, there have been "impartial" studies done that showed cigarette smoking to be "safe" done also.

What you should have bolded was:

In addition, no apparent differences were observed among groups in the 15-item panel of qualitative urine markers.

The only thing that really jumps out to me is that I'm having a hard time finding a full publication of this study, and I have access to EVERYTHING published in the US. I'd like to look in to what the urine and blood markers were, and whether or not they were measuring creatinin levels.

is that your way of syaing you were wrong? or am i still too "fucking retarded" to understand what you are saying?

It is bad enough that you resort to name calling during an argument. But when i provide the research that you say doesn't exist, why not just man-up and admit you were wrong? instead, you say i bolded the wrong part? give me a break.

[onetwo]

WHY cycle creatine?? Well first of all not everyone can afford every supplement they want. I cycle creatine to save money, imo there is no need to use it every day years straight

[Hbs6]

Originally Posted by onetwo

WHY cycle creatine?? Well first of all not everyone can afford every supplement they want. I cycle creatine to save money, imo there is no need to use it every day years straight

i think people were looking at it from a more physiological stand point than from a financial one.

[Hbs6]

and seriously no need for name calling

[MikeMartial]

Nice work Sledge. Another moron owned by science.

And yes, like Sonny stated, I've been taking creatine monohydrate for well over 4+ years now everyday; 5 grams on non-training days, 10 grams on training days. Prior to that, I cycled on and off since about 1991 or so.

I've never had an issue with creatine other than when I used to load 20 grams a day---then I noticed rapid weight gain and the increased need for hydration, much more so than at a steady 5 grams a day.