The 20/20 tv show interviewed this guy with no arms and no legs who wrestled in high school. He went on to say his handicap isn't going to stop him from doing anything. As much as I want to see the guy succeed in his dreams, I was floored by his closing comments--he talked about becoming a CAGE FIGHTER!!! Now, I think he might have an advantage in the sense that he can't be submitted by arm/legbars. On the other hand, he is going to have a serious disadvantage stopping the neck chokes, blocking the strikes, and performing his own strikes and submissions. I hope he comes to his senses before he gets killed. The sport of wrestling (and the protections it grants) is quite different from MMA.
(here is a internet article summary of the tv interview)
http://abcnews.go.com/2020/story?id=1171580&page=1