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Depends on what kind of running you're talking about. Generally in distance running eating will slow you down during the first twenty minutes or so, but later in the run when the food is digested you'll have more energy.
However, I wouldn't want to do any serious sprinting or anaerobic work with anything in my belly - in fact I always make sure to brush my teeth and use mouthwash to get any taste of food out of my mouth before I run. Nothing like burping up that mackerel dinner to throw you off your interval timing.
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